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Article

Roles for Dnmt3b in mammalian development: a mouse model for the ICF syndrome.

Development (Cambridge, England) - 1 Mar 2006

Ueda Yoshihide, Okano Masaki, Williams Christine, Chen Taiping, Georgopoulos Katia, Li En

Abstract excerpt

ICF (Immunodeficiency, Centromeric instability and Facial anomalies) syndrome is a rare autosomal recessive disease caused by mutations in the DNA methyltransferase gene DNMT3B. To investigate the function of Dnmt3b in mouse development and to create animal models for ICF syndrome, we have generated three mutant alleles of Dnmt3b in mice: one carrying a deletion of the catalytic domain (null allele) and two...

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Source

Identifiers

PMID: 16501171
DOI: 10.1242/dev.02293

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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