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Article

Developmental patterning of the cardiac atrioventricular canal by Notch and Hairy-related transcription factors

5 Oct 2006

Abstract excerpt

Mutations in Notch2, Jagged1 or homologs of the Hairy-related transcriptional repressor Hey2 cause congenital malformations involving the non-chamber atrioventricular canal (AVC) and inner curvature (IC) regions of the heart, but the underlying mechanisms have not been investigated. By manipulating signaling directly within the developing chick heart, we demonstrated that Notch2, Hey1 and Hey2 initiate a...

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PMID: 17021042
DOI: 10.1242/dev.02607

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