Tetralogy of fallot and other congenital heart defects in Hey2 mutant mice.

doi:10.1016/s0960-9822(02)01149-1

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Article

Tetralogy of fallot and other congenital heart defects in Hey2 mutant mice.

Current biology : CB - 17 Sept 2002

Donovan Jena, Kordylewska Anna, Jan Yuh Nung, Utset Manuel F

Abstract excerpt

Congenital malformations of the heart and circulatory system are the most common type of human birth defect. Recent studies have implicated the Notch signaling pathway in human cardiac development by demonstrating abnormalities of the JAG1 gene as the basis for Alagille syndrome and some cases of isolated tetralogy of Fallot or pulmonic stenosis. How the Notch pathway acts in cardiac development remains unknown,...

Topics

Animals
Calcium-Binding Proteins
Gene Targeting
Heart Defects, Congenital
Heart Septal Defects, Ventricular
Homozygote
Humans
Intercellular Signaling Peptides and Proteins
Jagged-1 Protein
Lac Operon
Membrane Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Mice, Inbred C57BL

Mice, Knockout

Mice, Transgenic

Phenotype

Proteins

Receptors, Notch

Source

Open in PubMed

Identifiers

PMID: 12372254
DOI: 10.1016/s0960-9822(02)01149-1

Genes

JAG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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