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Article

Deciphering Deleterious nsSNPs in MUC16's SEA Domain: Structural and Functional Implications in Cancer Metastasis via Computational Analysis.

Journal of cellular and molecular medicine - 1 Jun 2025

Faruque Muaz, Medha Maisha Maliha, Mahfuz A M U B, Islam Md Monirul, Siraj Md Afjalus

Abstract excerpt

MUC16 ranks among the top three genes exhibiting the highest mutation frequencies in various cancer types. It encodes transmembrane mucins present in the epithelial linings of the ocular, respiratory, gastric and female reproductive systems, serving to protect and maintain mucosal surfaces. Overexpression of MUC16 contributes to the differentiation, proliferation, invasion and metastasis of cancer cells in...

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Share to Amino Acid Sequence
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40478193
DOI: 10.1111/jcmm.70633
PMCID: PMC12143179

Genes

MUC16
SEA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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