Article

Functional characterization of germline variants in the <i>TMEM127</i> tumor suppressor reveals novel insights into its membrane topology and trafficking

2020-04-09

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Purpose</h4> To better understand the function of the transmembrane protein TMEM127, a poorly known tumor suppressor gene associated with pheochromocytomas, paragangliomas and renal carcinomas, we evaluated patient-derived germline variants. <h4>Methods</h4> Subcellular localization and steady-state levels of 21 tumor-associated, transiently expressed TMEM127 variants were compared to the...

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Literature Corpus work: 022198d2-c912-51a4-8444-dc52700f0862
DOI: 10.1101/2020.04.08.031039

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Functional characterization of germline variants in the <i>TMEM127</i> tumor suppressor reveals novel insights into its membrane topology and traffickingDOI 10.1101/2020.04.08.031039Read

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