Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

SLC24A5 encodes a trans-Golgi network protein with potassium-dependent sodium-calcium exchange activity that regulates human epidermal melanogenesis.

The Journal of biological chemistry - 29 Feb 2008

Ginger Rebecca S, Askew Sarah E, Ogborne Richard M, Wilson Stephen, Ferdinando Dudley, Dadd Tony, Smith Adrian M, Kazi Shubana, Szerencsei Robert T, Winkfein Robert J, Schnetkamp Paul P M, Green Martin R

Abstract excerpt

A non-synonymous single nucleotide polymorphism in the human SLC24A5 gene is associated with natural human skin color variation. Multiple sequence alignments predict that this gene encodes a member of the potassium-dependent sodium-calcium exchanger family denoted NCKX5. In cultured human epidermal melanocytes we show using affinity-purified antisera that native human NCKX5 runs as a triplet of approximately 43...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antiporters
Share to Golgi Apparatus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Ion Transport

Share to Melanins

Share to Melanocytes

Share to Potassium

Share to Sodium

Share to Sodium-Calcium Exchanger

Source

Identifiers

PMID: 18166528
DOI: 10.1074/jbc.M707521200

Genes

SDS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

SLC24A5 encodes a trans-Golgi network protein with potassium-dependent sodium-calcium exchange activity that regulates human epidermal melanogenesis.PMID 18166528Read ↗

NCKX5, a natural regulator of human skin colour variation, regulates the expression of key pigment genes MC1R and alpha-MSH and alters cholesterol homeostasis in normal human melanocytes.Semantic proximity Read ↗

The Role of SLC24A5 (NCKX5) in Human Skin Pigmentation: The Importance of Cation Transport Activity.Semantic proximity Read ↗

SLC24A5, a putative cation exchanger, affects pigmentation in zebrafish and humans.Semantic proximity Read ↗

A functional approach to understanding the role of NCKX5 in Xenopus pigmentation.Semantic proximity Read ↗

Cellular localization of the K+ -dependent Na+ -Ca2+ exchanger NCKX5 and the role of the cytoplasmic loop in its distribution in pigmented cells.Semantic proximity Read ↗

Molecular characterization of SLC24A5 variants and evaluation of Nitisinone treatment efficacy in a zebrafish model of OCA6.Semantic proximity Read ↗

Novel loss-of-function variant in DENND5A impedes melanosomal cargo transport and predisposes to familial cutaneous melanoma.Semantic proximity Read ↗

A golden age of human pigmentation genetics.Semantic proximity Read ↗

Comprehensive molecular and clinical characterization of SLC1A5 in human cancersSemantic proximity Read ↗

Exome sequencing identifies SLC24A5 as a candidate gene for nonsyndromic oculocutaneous albinism.Semantic proximity Read ↗

Common dominant-negative spectrum of SLC45A2 mutations in OCA4 defined by endoplasmic reticulum retention.Semantic proximity Read ↗

Sugar transporter SLC45 gene family members: roles in malignant tumors and research progress.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.