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Divergent molecular profile of PIK3CA gene in arsenic-associated bladder carcinoma.

Mutagenesis - 31 Dec 2020

Basu Mukta, Chakraborty Balarko, Ghosh Sabnam, Samadder Sudip, Dutta Sankhadeep, Roy Anup, Pal Dilip Kumar, Ghosh Amlan, Panda Chinmay Kumar

Abstract excerpt

The activation of PIK3CA in bladder carcinoma (BlCa) with its recurrent mutations in exon 9 and 20 were well reported. But the association of arsenic on the activation of the pathway is not well elucidated. Therefore, we aimed to analyse the effect of arsenic on the genetic (copy number variation/mutation) and expression profiles of PIK3CA in primary BlCa samples. Infrequent amplification (16%) of the PIK3CA...

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Identifiers

PMID: 33400797
DOI: 10.1093/mutage/geaa031

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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