Article
PIK3CA gene alterations in bladder cancer are frequent and associate with reduced recurrence in non-muscle invasive tumors.
Molecular carcinogenesis - 1 Jul 2015
Dueñas Marta, Martínez-Fernández Mónica, García-Escudero Ramón, Villacampa Felipe, Marqués Miriam, Saiz-Ladera Cristina, Duarte José, Martínez Victor, Gómez M José, Martín M Luisa, Fernández Manoli, Castellano Daniel, Real Francisco X, Rodriguez-Peralto Jose L, De La Rosa Federico, Paramio Jesús M
Abstract excerpt
Bladder cancer (BC) is the fifth most common cancer in the world, being the non-muscle invasive tumors (NMIBC) the most frequent. NMIBC shows a very high frequency of recurrence and, in certain cases, tumor progression. The phosphatidylinositol 3-kinase (PI3K) pathway, which controls cell growth, tumorigenesis, cell invasion and drug response, is frequently activated in numerous human cancers, including BC, in...
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