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Article

Heterogeneous polymerase fidelity and mismatch repair bias genome variation and composition.

Genome research - 1 Nov 2014

Lujan Scott A, Clausen Anders R, Clark Alan B, MacAlpine Heather K, MacAlpine David M, Malc Ewa P, Mieczkowski Piotr A, Burkholder Adam B, Fargo David C, Gordenin Dmitry A, Kunkel Thomas A

Abstract excerpt

Mutational heterogeneity must be taken into account when reconstructing evolutionary histories, calibrating molecular clocks, and predicting links between genes and disease. Selective pressures and various DNA transactions have been invoked to explain the heterogeneous distribution of genetic variation between species, within populations, and in tissue-specific tumors. To examine relationships between such...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25217194
DOI: 10.1101/gr.178335.114
PMCID: PMC4216917

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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