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Article

XBP1s repression regulates Kupffer cell polarization leading to immune suppressive effects protecting liver allograft in rats.

International immunopharmacology - 1 Feb 2021

Zhang Weikang, Cao Ding, Wang Menghao, Wu Yakun, Gong Jianping, Li Jingzheng, Liu Yiming

Abstract excerpt

BACKGROUND: Polarized kupffer cells (KCs) influence the immune response after liver transplantation. We report an undiscovered immune regulatory role of X-box binding protein 1 (XBP1) on immune function of kupffer cells (KCs). METHODS: Acute rejection model using rats. RESULTS: We found that suppression of XBP1s in lipopolysaccharide (LPS) -activated KCs could increase the expression of arginase-1 (Arg-1) and...

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PMID: 33395585
DOI: 10.1016/j.intimp.2020.107294

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