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Article

Strategies for Deliberate Induction of Immune Tolerance in Liver Transplantation: From Preclinical Models to Clinical Application.

Frontiers in immunology - 1 Jan 2020

Tanimine Naoki, Ohira Masahiro, Tahara Hiroyuki, Ide Kentaro, Tanaka Yuka, Onoe Takashi, Ohdan Hideki

Abstract excerpt

The liver exhibits intrinsic immune regulatory properties that maintain tolerance to endogenous and exogenous antigens, and provide protection against pathogens. Such an immune privilege contributes to susceptibility to spontaneous acceptance despite major histocompatibility complex mismatch when transplanted in animal models. Furthermore, the presence of a liver allograft can suppress the rejection of other...

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Source

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Identifiers

PMID: 32849546
DOI: 10.3389/fimmu.2020.01615
PMCID: PMC7412931

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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