Article
IL-34 Inhibits Acute Rejection of Rat Liver Transplantation by Inducing Kupffer Cell M2 Polarization.
Transplantation - 1 Jun 2018
Zhao Zhengfei, Pan Guangrui, Tang Chengyong, Li Zhongtang, Zheng Daofeng, Wei Xufu, Wu Zhongjun
Abstract excerpt
BACKGROUND: Recent studies have demonstrated that IL-34 is implicated in the regulation of macrophage functions. However, the effect of IL-34 on Kupffer cells (KCs) in acute rejection (AR) of liver transplantation remains unclear. METHODS: IL-34 expression was detected in graft and serum from allotransplantation and syngeneic transplantation groups. The adeno-associated virus-expressing IL-34 was used to assess...
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