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Article

Btk regulates macrophage polarization in response to lipopolysaccharide.

PloS one - 1 Jan 2014

Ní Gabhann Joan, Hams Emily, Smith Siobhán, Wynne Claire, Byrne Jennifer C, Brennan Kiva, Spence Shaun, Kissenpfennig Adrien, Johnston James A, Fallon Padraic G, Jefferies Caroline A

Abstract excerpt

Bacterial Lipopolysaccharide (LPS) is a strong inducer of inflammation and does so by inducing polarization of macrophages to the classic inflammatory M1 population. Given the role of Btk as a critical signal transducer downstream of TLR4, we investigated its role in M1/M2 induction. In Btk deficient (Btk (-\-)) mice we observed markedly reduced recruitment of M1 macrophages following intraperitoneal...

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Share to Lipopolysaccharides
Share to Agammaglobulinaemia Tyrosine Kinase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Polarity

Share to Hypersensitivity

Share to Macrophages

Share to Macrophages, Peritoneal

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Source

Open in PubMed Open full text

Identifiers

PMID: 24465735
DOI: 10.1371/journal.pone.0085834
PMCID: PMC3897530

Genes

STAT1
STAT6
TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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