Article
Whole exome sequencing and system biology analysis support the "two-hit" mechanism in the onset of Ameloblastoma.
Medicina oral, patologia oral y cirugia bucal - 1 Jul 2021
Shi Y, Li M, Yu Y, Zhou Y, Wang S
Abstract excerpt
BACKGROUND: Ameloblastoma is the most frequent odontogenic tumor. Various evidence has highlighted the role of somatic mutations, including recurrent mutation BRAF V600E, in the tumorigenesis of Ameloblastoma, but the intact genetic pathology remains unknown. MATERIAL AND METHODS: We sequenced the whole exome of both tumor tissue and healthy bone tissue from four mandibular ameloblastoma patients. The identified...
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