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Discovery of novel molecular characteristics and cellular biological properties in ameloblastoma.

Cancer medicine - 1 Apr 2020

Kondo Sayuri, Ota Akinobu, Ono Takayuki, Karnan Sivasundaram, Wahiduzzaman Md, Hyodo Toshinori, Lutfur Rahman Md, Ito Kunihiro, Furuhashi Akifumi, Hayashi Tomio, Konishi Hiroyuki, Tsuzuki Shinobu, Hosokawa Yoshitaka, Kazaoka Yoshiaki

Abstract excerpt

Ameloblastoma is a rare odontogenic benign tumor accounting for less than 1% of head and neck tumors. Advanced next generation sequencing (NGS) analyses identified high frequency of BRAF V600E and SMO L412F mutations in ameloblastoma. Despite the existence of whole genomic sequence information from patients with ameloblastoma, entire molecular signature of and the characteristics of ameloblastoma cells are still...

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PMID: 32096304
DOI: 10.1002/cam4.2931
PMCID: PMC7163100

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