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Article

Binding characteristics of calpastatin domain L to NaV1.5 sodium channel and its IQ motif mutants.

Biochemical and biophysical research communications - 30 Oct 2022

Zhang Fenghui, Xue Yingchun, Su Jingyang, Xu Xingrong, Zhao Yifan, Liu Yan, Hu Huiyuan, Hao Liying

Abstract excerpt

NaV1.5 channel is an integral membrane protein involved in the initiation and conduction of action potentials. IQ motif is located in the C-terminal domain of NaV1.5 sodium channel, which is highly conserved in human sodium channel subtypes. IQ motif is involved in the Ca2+-dependent regulation through interaction with the regulatory proteins such as calpastatin domain L (CSL). Mutations in SCN5A, the gene...

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PMID: 36007333
DOI: 10.1016/j.bbrc.2022.07.056

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