Article
High-Density-Immune-Complex Regulatory Macrophages Promote Recovery of Experimental Colitis in Mice.
Inflammation - 1 Jun 2021
Lopes Tamara Cristina Moreira, Almeida Gregório Guilherme, Souza Izabela Aparecida, Borges Diego Costa, de Lima Wanderson Geraldo, Prazeres Pedro Henrique Dias Moura, Birbrair Alexander, Arantes Rosa Maria Esteves, Mosser David M, Goncalves Ricardo
Abstract excerpt
Macrophages not only play a fundamental role in the pathogenesis of inflammatory bowel disease (IBD), but they also play a major role in preserving intestinal homeostasis. In this work, we evaluated the role of macrophages in IBD and investigated whether the functional reprogramming of macrophages to a very specific phenotype could decrease disease pathogenesis. Thus, macrophages were stimulated in the presence...
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