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Article

Macrophage Immune Memory Controls Endometriosis in Mice and Humans.

Cell reports - 3 Nov 2020

Jeljeli Mohamed, Riccio Luiza G C, Chouzenoux Sandrine, Moresi Fabiana, Toullec Laurie, Doridot Ludivine, Nicco Carole, Bourdon Mathilde, Marcellin Louis, Santulli Pietro, Abrão Mauricio S, Chapron Charles, Batteux Frédéric

Abstract excerpt

Endometriosis is a frequent, chronic, inflammatory gynecological disease characterized by the presence of ectopic endometrial tissue causing pain and infertility. Macrophages have a central role in lesion establishment and maintenance by driving chronic inflammation and tissue remodeling. Macrophages can be reprogrammed to acquire memory-like characteristics after antigenic challenge to reinforce or inhibit a...

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PMID: 33147452
DOI: 10.1016/j.celrep.2020.108325

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