Article
Quorum Sensing by Gelsolin Regulates Programmed Cell Death 4 Expression and a Density-Dependent Phenotype in Macrophages.
Journal of immunology (Baltimore, Md. : 1950) - 1 Sept 2021
Sharma Reshma Kumari, Goswami Binita, Das Mandal Sukhen, Guha Abhishek, Willard Belinda, Ray Partho Sarothi
Abstract excerpt
Quorum-sensing mechanisms that sense the density of immune cells at the site of inflammation to initiate inflammation resolution have recently been demonstrated as a major determinant of the inflammatory response. We observed a density-dependent increase in expression of the inflammatory tumor suppressor protein programmed cell death 4 (PDCD4) in mouse macrophage cells. Conditioned medium from high-density cells...
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