Article
CLEC-2 Prevents Accumulation and Retention of Inflammatory Macrophages During Murine Peritonitis.
Frontiers in immunology - 1 Jan 2021
Bourne Joshua H, Beristain-Covarrubias Nonantzin, Zuidscherwoude Malou, Campos Joana, Di Ying, Garlick Evelyn, Colicchia Martina, Terry Lauren V, Thomas Steven G, Brill Alexander, Bayry Jagadeesh, Watson Steve P, Rayes Julie
Abstract excerpt
Platelets play a key role in the development, progression and resolution of the inflammatory response during sterile inflammation and infection, although the mechanism is not well understood. Here we show that platelet CLEC-2 reduces tissue inflammation by regulating inflammatory macrophage activation and trafficking from the inflamed tissues. The immune regulatory function of CLEC-2 depends on the expression of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.