Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

STK11 loss drives rapid progression in a breast cancer patient resulting in pulmonary tumor thrombotic microangiopathy.

Breast cancer (Tokyo, Japan) - 1 May 2021

Fujisawa Fumie, Kunimasa Kei, Kano-Fujiwara Rieko, Sato Yoshiharu, Kusama Hiroki, Nishio Minako, Matsui Saki, Yoshinami Tetsuhiro, Kittaka Nobuyoshi, Nakamura Harumi, Nagata Shigenori, Honma Keiichiro, Yagi Toshinari, Nakayama Takahiro, Tamaki Yasuhiro, Imamura Fumio

Abstract excerpt

We experienced a case of breast cancer in which liver metastases spread rapidly and the patient died of pulmonary tumor thrombotic microangiopathy (PTTM). PTTM is a fatal cancer-associated respiratory complication disease. To reveal genetic alterations of the clinical course, we performed next generation sequencing of the serial specimens using the Ion AmpliSeqTM Comprehensive Cancer Panel and RNA sequencing for...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to AMP-Activated Protein Kinase Kinases
Share to Breast Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Carcinoma, Ductal, Breast

Share to Fatal Outcome

Share to High-Throughput Nucleotide Sequencing

Share to Liver Neoplasms

Share to Mutation

Share to Protein Serine-Threonine Kinases

Source

Identifiers

PMID: 33389615
DOI: 10.1007/s12282-020-01200-1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

STK11 loss drives rapid progression in a breast cancer patient resulting in pulmonary tumor thrombotic microangiopathy.PMID 33389615Read ↗

STK11 (LKB1) missense somatic mutant isoforms promote tumor growth, motility and inflammationSemantic proximity Read ↗

Genomic Profiling Identifies Somatic Mutations Predicting Thromboembolic Risk in Patients with Solid TumorsSemantic proximity Read ↗

Multiomic profiling of LKB1 loss of expression in breast cancerSemantic proximity Read ↗

Genomic profiling identifies somatic mutations predicting thromboembolic risk in patients with solid tumors.Semantic proximity Read ↗

Metastatic triple-negative breast cancer patient with TP53 tumor mutation experienced 11 months progression-free survival on bortezomib monotherapy without adverse events after ending standard treatments with grade 3 adverse events.Semantic proximity Read ↗

Recurrent PTPRB and PLCG1 mutations in angiosarcoma.Semantic proximity Read ↗

Two progressed malignant phyllodes tumors of the breast harbor alterations in genes frequently involved in other advanced cancers.Semantic proximity Read ↗

Whole-exome sequencing identifies recurrent AKT1 mutations in sclerosing hemangioma of lung.Semantic proximity Read ↗

Establishing associations of thrombospondin linked to tumor growth, with thrombosisSemantic proximity Read ↗

STK10 missense mutations associated with anti-apoptotic function.Semantic proximity Read ↗

PIK3CA mutation fortifies molecular determinants for immune signaling in vascular cancers.Semantic proximity Read ↗

Constitutively active PIK3CA mutations are expressed by lymphatic and vascular endothelial cells in capillary lymphatic venous malformation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.