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Article

PIK3CA mutation fortifies molecular determinants for immune signaling in vascular cancers.

Cancer gene therapy - 1 Feb 2025

Lee Donghee, Kozurek Emma C, Abdullah Md, Wong Ethan J, Li Rong, Liu Zhiyan Silvia, Nguyen Hai Dang, Dickerson Erin B, Kim Jong Hyuk

Abstract excerpt

Angiosarcomas are a group of vascular cancers that form malignant blood vessels. These malignancies are seemingly inflamed primarily due to their pathognomonic nature, which consists of irregular endothelium and tortuous blood channels. PIK3CA mutations are oncogenic and disrupt the PI3K pathway. In this study, we aimed to define the molecular and functional consequences of oncogenic PIK3CA mutations in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39709507
DOI: 10.1038/s41417-024-00867-4
PMCID: PMC11839470

Genes

PIK3CA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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