Article
Genomic profiling identifies somatic mutations predicting thromboembolic risk in patients with solid tumors.
Blood - 15 Apr 2021
Dunbar Andrew, Bolton Kelly L, Devlin Sean M, Sanchez-Vega Francisco, Gao Jianjiong, Mones Jodi V, Wills Jonathan, Kelly Daniel, Farina Mirko, Cordner Keith B, Park Young, Kishore Sirish, Juluru Krishna, Iyengar Neil M, Levine Ross L, Zehir Ahmet, Park Wungki, Khorana Alok A, Soff Gerald A, Mantha Simon
Abstract excerpt
Venous thromboembolism (VTE) associated with cancer (CAT) is a well-described complication of cancer and a leading cause of death in patients with cancer. The purpose of this study was to assess potential associations of molecular signatures with CAT, including tumor-specific mutations and the presence of clonal hematopoiesis. We analyzed deep-coverage targeted DNA-sequencing data of >14 000 solid tumor samples...
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