Article

Multiomic profiling of LKB1 loss of expression in breast cancer

2026-06-19

Abstract excerpt

<h4>ABSTRACT</h4> The tumour suppressor LKB1 (STK11) is implicated in diverse cancers, yet its transcriptomic role in breast cancer remains poorly defined. Here, we integrate bulk-tumour genomic analysis of the METABRIC cohort, CRISPR-Cas9-mediated STK11 knockout in human breast cancer cell lines, single-cell RNA sequencing of patient tumours, and a novel Lkb1 murine model to characterise LKB1-dependent transcr...

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Literature Corpus work: bfec1903-f221-5da4-80a2-c00e01ab911c
DOI: 10.64898/2026.06.17.732963

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