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Article

Solution structure of SHIP2 SH2 domain and its interaction with a phosphotyrosine peptide from c-MET.

Archives of biochemistry and biophysics - 15 Oct 2018

Wang Zi, Nie Yao, Zhang Kunxiao, Xu Henghao, Ramelot Theresa A, Kennedy Michael A, Liu Maili, Zhu Jiang, Yang Yunhuang

Abstract excerpt

SH2 domain-containing inositol 5-phosphatase 2 (SHIP2) binds with the Y1356-phosphorylated hepatocyte growth factor (HGF) receptor, c-MET, through its SH2 domain, which is essential for the role of SHIP2 in HGF-induced cell scattering and cell spreading. Previously, the experimental structure of the SH2 domain from SHIP2 (SHIP2-SH2) had not been reported, and its interaction with the Y1356-phosphorylated c-MET...

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Identifiers

PMID: 30165040
DOI: 10.1016/j.abb.2018.08.012
PMCID: PMC6251712

Genes

MET
HGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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