Article
The A118G single-nucleotide polymorphism in OPRM1 is a risk factor for asthma severity.
Allergology international : official journal of the Japanese Society of Allergology - 1 Jan 2022
Kawakami Kaori, Miyasaka Tomomitsu, Nakamura Yutaka, Metoki Hirohito, Miyata Satoshi, Sato Miki, Sora Ichiro, Yamauchi Kohei, Kawakami Kazuyoshi, Blendy Julie A, Kawano Tasuku, Shimokawa Hiroaki, Takayanagi Motoaki, Ohno Isao, Takahashi Tomoko
Abstract excerpt
BACKGROUND: Although population studies have implicated emotional burden in asthma severity, the underlying genetic risk factors are not completely understood. We aimed to evaluate the genetic influence of a functional single-nucleotide polymorphism (SNP) in the stress-related μ-opioid receptor gene (OPRM1; A118G SNP, rs1799971) on asthma severity. METHODS: We initially assessed disease severity in asthmatic...
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