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Article

Toll-like receptor 4 polymorphism and severity of atopy in asthmatics.

Genes and immunity - 1 Jan 2004

Yang I A, Barton S J, Rorke S, Cakebread J A, Keith T P, Clough J B, Holgate S T, Holloway J W

Abstract excerpt

Endotoxin exposure may have a protective effect against asthma and atopy. An Asp299Gly polymorphism in the Toll-like receptor 4 (TLR4) gene reduces responsiveness to endotoxin. This study determined the effect of TLR4 polymorphism on the risk and severity of asthma and atopy. In all, 336 UK Caucasian families with > or = 2 affected sibs (physician's diagnosis of asthma and current medication use) and 179...

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Source

Identifiers

PMID: 14735148
DOI: 10.1038/sj.gene.6364037

Genes

TLR4
FEV

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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