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Article

Toll-like receptor 4 polymorphism and severity of atopy in asthmatics.

Genes and immunity - 1 Jan 2004

Yang I A, Barton S J, Rorke S, Cakebread J A, Keith T P, Clough J B, Holgate S T, Holloway J W

Abstract excerpt

Endotoxin exposure may have a protective effect against asthma and atopy. An Asp299Gly polymorphism in the Toll-like receptor 4 (TLR4) gene reduces responsiveness to endotoxin. This study determined the effect of TLR4 polymorphism on the risk and severity of asthma and atopy. In all, 336 UK Cauca...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 14735148
DOI: 10.1038/sj.gene.6364037

Genes

TLR4
FEV

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-14735148-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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