Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Multivariate genome wide association and network analysis of subcortical imaging phenotypes in Alzheimer's disease.

BMC genomics - 29 Dec 2020

Meng Xianglian, Li Jin, Zhang Qiushi, Chen Feng, Bian Chenyuan, Yao Xiaohui, Yan Jingwen, Xu Zhe, Risacher Shannon L, Saykin Andrew J, Liang Hong, Shen Li

Abstract excerpt

BACKGROUND: Genome-wide association studies (GWAS) have identified many individual genes associated with brain imaging quantitative traits (QTs) in Alzheimer's disease (AD). However single marker level association discovery may not be able to address the underlying biological interactions with disease mechanism. RESULTS: In this paper, we used the MGAS (Multivariate Gene-based Association test by extended Simes...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer Disease
Share to Brain

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to APOC1 gene

Share to Genetic Predisposition to Disease

Share to Genome-Wide Association Study

Share to Phenotype

Share to Polymorphism, Single Nucleotide

Share to Protein Interaction Maps

Source

Open in PubMed Open full text

Identifiers

PMID: 33372590
DOI: 10.1186/s12864-020-07282-7
PMCID: PMC7771059

Genes

APOC1
APOE
LAMA1
NPEPL1
TOMM40
XYLB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Multivariate genome wide association and network analysis of subcortical imaging phenotypes in Alzheimer's disease.PMID 33372590Read ↗

Genome-wide network-based pathway analysis of CSF t-tau/Aβ1-42 ratio in the ADNI cohort.Semantic proximity Read ↗

Multi-Omics Integration Analysis Pinpoint Proteins Influencing Brain Structure and Function: Toward Drug Targets and Neuroimaging Biomarkers for Neuropsychiatric Disorders.Semantic proximity Read ↗

Genome-wide Network-assisted Association and Enrichment Study of Amyloid Imaging Phenotype in Alzheimer's Disease.Semantic proximity Read ↗

A large scale multivariate parallel ICA method reveals novel imaging-genetic relationships for Alzheimer's disease in the ADNI cohort.Semantic proximity Read ↗

Hippocampal transcriptome profiling combined with protein-protein interaction analysis elucidates Alzheimer's disease pathways and genesSemantic proximity Read ↗

Mining Alzheimer's Interactomes, Macromolecular Complexes and Pathways for drug discoverySemantic proximity Read ↗

Integrative Multiomics Insights into the Genetic and Epigenetic Architecture of Alzheimer's Disease.Semantic proximity Read ↗

Proteome-wide association studies using summary pQTL data of three tissues identified 30 risk genes of Alzheimer’s disease dementiaSemantic proximity Read ↗

A telescope GWAS analysis strategy, based on SNPs-genes-pathways ensamble and on multivariate algorithms, to characterize late onset Alzheimer's disease.Semantic proximity Read ↗

Quantitative Trait Module-Based Genetic Analysis of Alzheimer's Disease.Semantic proximity Read ↗

Genome-wide interaction analysis of pathological hallmarks in Alzheimer's disease.Semantic proximity Read ↗

Proteome-wide association studies using summary pQTL data of brain, CSF, and plasma identify 30 risk genes of Alzheimer's disease dementia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.