Article

Mining Alzheimer's Interactomes, Macromolecular Complexes and Pathways for drug discovery

2025-01-10

Abstract excerpt

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder that leads to dementia. Many cases are diagnosed annually and there is no currently available cure. Understanding the underlying disease biology of AD through the study of molecular networks, particularly by mapping clinical variants to tissue-specific interactomes and regulatory macromolecular assemblies, offers a promising avenue to elucidate a...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9909a305-c5bb-51e3-a295-20bc6c28eac4
DOI: 10.22541/au.173650341.16229162/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Mining Alzheimer's Interactomes, Macromolecular Complexes and Pathways for drug discoveryDOI 10.22541/au.173650341.16229162/v1Read

Mining Alzheimer's Interactomes, Macromolecular Complexes and Pathways for Drug Discovery.Semantic proximity Read

An Integrated Molecular Atlas of Alzheimer’s DiseaseSemantic proximity Read

Interactome mapping suggests new mechanistic details underlying Alzheimer's disease.Semantic proximity Read

Integrated proteomics and network analysis identifies protein hubs and network alterations in Alzheimer’s diseaseSemantic proximity Read

An Integrative Network-based Analysis Reveals Gene Networks, Biological Mechanisms, and Novel Drug Targets in Alzheimer’s DiseaseSemantic proximity Read

Genome-wide prediction and integrative functional characterization of Alzheimer’s disease-associated genesSemantic proximity Read

Integrative Multiomics Insights into the Genetic and Epigenetic Architecture of Alzheimer's Disease.Semantic proximity Read

Mapping cross-domain drivers of Alzheimer’s disease risk through integrated network analysisSemantic proximity Read

Large-scale deep multi-layer analysis of Alzheimer’s disease brain reveals strong proteomic disease-related changes not observed at the RNA levelSemantic proximity Read

Deep proteomic network analysis of Alzheimer’s disease brain reveals alterations in RNA binding proteins and RNA splicing associated with diseaseSemantic proximity Read

A Network-based Deep Learning Framework Catalyzes GWAS and Multi-Omics Findings to Biology and Drug Repurposing for Alzheimer’s DiseaseSemantic proximity Read

AlzPathway: a comprehensive map of signaling pathways of Alzheimer's disease.Semantic proximity Read