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Article

Distinct effects of two hearing loss-associated mutations in the sarcomeric myosin MYH7b.

The Journal of biological chemistry - 1 May 2023

Lee Lindsey A, Barrick Samantha K, Buvoli Ada E, Walklate Jonathan, Stump W Tom, Geeves Michael, Greenberg Michael J, Leinwand Leslie A

Abstract excerpt

For decades, sarcomeric myosin heavy chain proteins were assumed to be restricted to striated muscle where they function as molecular motors that contract muscle. However, MYH7b, an evolutionarily ancient member of this myosin family, has been detected in mammalian nonmuscle tissues, and mutations in MYH7b are linked to hereditary hearing loss in compound heterozygous patients. These mutations are the first...

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Identifiers

PMID: 36963494
DOI: 10.1016/j.jbc.2023.104631
PMCID: PMC10141508

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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