Article
Artemisinin resistance without pfkelch13 mutations in Plasmodium falciparum isolates from Cambodia.
Malaria journal - 12 May 2017
Mukherjee Angana, Bopp Selina, Magistrado Pamela, Wong Wesley, Daniels Rachel, Demas Allison, Schaffner Stephen, Amaratunga Chanaki, Lim Pharath, Dhorda Mehul, Miotto Olivo, Woodrow Charles, Ashley Elizabeth A, Dondorp Arjen M, White Nicholas J, Wirth Dyann, Fairhurst Rick, Volkman Sarah K
Abstract excerpt
BACKGROUND: Artemisinin resistance is associated with delayed parasite clearance half-life in vivo and correlates with ring-stage survival under dihydroartemisinin in vitro. Both phenotypes are associated with mutations in the PF3D7_1343700 pfkelch13 gene. Recent spread of artemisinin resistance and emerging piperaquine resistance in Southeast Asia show that artemisinin combination therapy, such as...
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