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Integrative network analysis reveals different pathophysiological mechanisms of insulin resistance among Caucasians and African Americans

6 Feb 2015

Abstract excerpt

BACKGROUND: African Americans (AA) have more pronounced insulin resistance and higher insulin secretion than European Americans (Caucasians or CA) when matched for age, gender, and body mass index (BMI). We hypothesize that physiological differences (including insulin sensitivity [SI]) between CAs and AAs can be explained by co-regulated gene networks in tissues involved in glucose homeostasis. METHODS: We...

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PMID: 25868721
DOI: 10.1186/s12920-015-0078-0

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