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Article

Novel CRISPR-based sequence specific enrichment methods for target loci and single base mutations.

PloS one - 1 Jan 2020

Steele Jennifer L, Stevens Richard C, Cabrera Oscar A, Bassill Gary J, Cramer Sabrina M, Guzman Felipe, Shuber Anthony P

Abstract excerpt

The programmable sequence specificity of CRISPR has found uses in gene editing and diagnostics. This manuscript describes an additional application of CRISPR through a family of novel DNA enrichment technologies. CAMP (CRISPR Associated Multiplexed PCR) and cCAMP (chimeric CRISPR Associated Multiplexed PCR) utilize the sequence specificity of the Cas9/sgRNA complex to target loci for the ligation of a universal...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 33362267
DOI: 10.1371/journal.pone.0243781
PMCID: PMC7757808

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Source receipt: pubmed, retrieved 7 Sept 2026.

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