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Article

CRISPR-Cap: multiplexed double-stranded DNA enrichment based on the CRISPR system.

Nucleic acids research - 10 Jan 2019

Lee Jeewon, Lim Hyeonseob, Jang Hoon, Hwang Byungjin, Lee Joon Ho, Cho Junhyuk, Lee Ji Hyun, Bang Duhee

Abstract excerpt

Existing methods to enrich target regions of genomic DNA based on PCR, hybridization capture, or molecular inversion probes have various drawbacks, including long experiment times and low throughput and/or enrichment quality. We developed CRISPR-Cap, a simple and scalable CRISPR-based method to enrich target regions of dsDNA, requiring only two short experimental procedures that can be completed within two hours....

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PMID: 30215766
DOI: 10.1093/nar/gky820
PMCID: PMC6326800

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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