Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Radixin modulates the function of outer hair cell stereocilia.

Communications biology - 23 Dec 2020

Prasad Sonal, Vona Barbara, Diñeiro Marta, Costales María, González-Aguado Rocío, Fontalba Ana, Diego-Pérez Clara, Subasioglu Asli, Bademci Guney, Tekin Mustafa, Cabanillas Rubén, Cadiñanos Juan, Fridberger Anders

Abstract excerpt

The stereocilia of the inner ear sensory cells contain the actin-binding protein radixin, encoded by RDX. Radixin is important for hearing but remains functionally obscure. To determine how radixin influences hearing sensitivity, we used a custom rapid imaging technique to visualize stereocilia motion while measuring electrical potential amplitudes during acoustic stimulation. Radixin inhibition decreased...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Arsenicals
Share to Acoustic Stimulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytoskeletal Proteins

Share to Fluorescent Antibody Technique

Share to Guinea Pigs

Share to Hair Cells, Auditory, Outer

Share to Hearing Loss

Share to Mechanotransduction, Cellular

Source

Open in PubMed Open full text

Identifiers

PMID: 33361775
DOI: 10.1038/s42003-020-01506-y
PMCID: PMC7758333

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Radixin modulates the function of outer hair cell stereocilia.PMID 33361775Read ↗

Radixin deficiency causes deafness associated with progressive degeneration of cochlear stereocilia.Semantic proximity Read ↗

Mutations of the RDX gene cause nonsyndromic hearing loss at the DFNB24 locus.Semantic proximity Read ↗

Neuroplastin Isoform Np55 Is Expressed in the Stereocilia of Outer Hair Cells and Required for Normal Outer Hair Cell Function.Semantic proximity Read ↗

Single-cell analysis of Rohon-Beard neurons implicates Fgf signaling in axon maintenance and cell survivalSemantic proximity Read ↗

The BEACH protein LRBA is required for hair bundle maintenance in cochlear hair cells and for hearing.Semantic proximity Read ↗

Long isoforms of Espin and Espin-Like proteins are essential for development and maintenance of mechanotransducing stereocilia.Semantic proximity Read ↗

The MEC-4 DEG/ENaC channel of Caenorhabditis elegans touch receptor neurons transduces mechanical signals.Semantic proximity Read ↗

Transcriptomic Classification of Neurons Innervating TeethSemantic proximity Read ↗

Whisker stimulation alleviate ASD behavior of BTBR mice by regulating Piezo2 expression in DRG and neuron function in S1 and mPFCSemantic proximity Read ↗

Mutation of Npr2 leads to blurred tonotopic organization of central auditory circuits in mice.Semantic proximity Read ↗

Grxcr2 is required for stereocilia morphogenesis in the cochlea.Semantic proximity Read ↗

Best1 is a gene regulated by nerve injury and required for Ca2+-activated Cl- current expression in axotomized sensory neurons.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.