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Article

The BEACH protein LRBA is required for hair bundle maintenance in cochlear hair cells and for hearing.

EMBO reports - 1 Nov 2017

Vogl Christian, Butola Tanvi, Haag Natja, Hausrat Torben J, Leitner Michael G, Moutschen Michel, Lefèbvre Philippe P, Speckmann Carsten, Garrett Lillian, Becker Lore, Fuchs Helmut, Hrabe de Angelis Martin, Nietzsche Sandor, Kessels Michael M, Oliver Dominik, Kneussel Matthias, Kilimann Manfred W, Strenzke Nicola

Abstract excerpt

Lipopolysaccharide-responsive beige-like anchor protein (LRBA) belongs to the enigmatic class of BEACH domain-containing proteins, which have been attributed various cellular functions, typically involving intracellular protein and membrane transport processes. Here, we show that LRBA deficiency in mice leads to progressive sensorineural hearing loss. In LRBA knockout mice, inner and outer hair cell stereociliary...

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Share to Cytoskeletal Proteins
Share to Evoked Potentials, Auditory, Brain Stem

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hair Cells, Auditory

Share to Hearing

Share to Hearing Loss, Sensorineural

Share to Phosphoproteins

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Source

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Identifiers

PMID: 28893864
DOI: 10.15252/embr.201643689
PMCID: PMC5666617

Genes

LRBA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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