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Article

Neuroplastin Isoform Np55 Is Expressed in the Stereocilia of Outer Hair Cells and Required for Normal Outer Hair Cell Function.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 31 Aug 2016

Zeng Wei-Zheng, Grillet Nicolas, Dewey James B, Trouillet Alix, Krey Jocelyn F, Barr-Gillespie Peter G, Oghalai John S, Müller Ulrich

Abstract excerpt

UNLABELLED: Neuroplastin (Nptn) is a member of the Ig superfamily and is expressed in two isoforms, Np55 and Np65. Np65 regulates synaptic transmission but the function of Np55 is unknown. In an N-ethyl-N-nitrosaurea mutagenesis screen, we have now generated a mouse line with an Nptn mutation that causes deafness. We show that Np55 is expressed in stereocilia of outer hair cells (OHCs) but not inner hair cells...

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Share to Acoustic Stimulation
Share to Evoked Potentials, Auditory, Brain Stem

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hair Cells, Auditory, Inner

Share to Hair Cells, Auditory, Outer

Share to Mechanotransduction, Cellular

Share to Otoacoustic Emissions, Spontaneous

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Share to Transduction, Genetic

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Identifiers

PMID: 27581460
DOI: 10.1523/JNEUROSCI.0093-16.2016
PMCID: PMC5005726

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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