Article
Grxcr2 is required for stereocilia morphogenesis in the cochlea.
PloS one - 1 Jan 2018
Avenarius Matthew R, Jung Jae-Yun, Askew Charles, Jones Sherri M, Hunker Kristina L, Azaiez Hela, Rehman Atteeq U, Schraders Margit, Najmabadi Hossein, Kremer Hannie, Smith Richard J H, Géléoc Gwenaëlle S G, Dolan David F, Raphael Yehoash, Kohrman David C
Abstract excerpt
Hearing and balance depend upon the precise morphogenesis and mechanosensory function of stereocilia, the specialized structures on the apical surface of sensory hair cells in the inner ear. Previous studies of Grxcr1 mutant mice indicated a critical role for this gene in control of stereocilia dimensions during development. In this study, we analyzed expression of the paralog Grxcr2 in the mouse and evaluated...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.