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Article

Network dysfunction in<i>α</i>‐synuclein transgenic mice and human Lewy body dementia

16 Oct 2015

Abstract excerpt

OBJECTIVE: Dementia with Lewy bodies (DLB) is associated with the accumulation of wild-type human α-synuclein (SYN) in neurons and with prominent slowing of brain oscillations on electroencephalography (EEG). However, it remains uncertain whether the EEG abnormalities are actually caused by SYN. METHODS: To determine whether SYN can cause neural network abnormalities, we performed EEG recordings and analyzed the...

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PMID: 26732627
DOI: 10.1002/acn3.257

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