Pde8b haploinsufficiency in mice is associated with modest adrenal defects, impaired steroidogenesis, and male infertility, unaltered by concurrent PKA or Wnt activation.

doi:10.1016/j.mce.2020.111117

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Article

Pde8b haploinsufficiency in mice is associated with modest adrenal defects, impaired steroidogenesis, and male infertility, unaltered by concurrent PKA or Wnt activation.

Molecular and cellular endocrinology - 15 Feb 2021

Leal Leticia Ferro, Szarek Eva, Berthon Annabel, Nesterova Maria, Faucz Fabio R, London Edra, Mercier Christopher, Abu-Asab Mones, Starost Matthew F, Dye Louis, Bilinska Barbara, Kotula-Balak Malgorzata, Antonini Sonir R, Stratakis Constantine A

Abstract excerpt

PDE8B, PRKAR1A and the Wnt/β-catenin signaling are involved in endocrine disorders. However, how PDEB8B interacts with both Wnt and protein kinase A (PKA) signaling in vivo remains unknown. We created a novel Pde8b knockout mouse line (Pde8b-/-); Pde8b haploinsufficient (Pde8b+/-) mice were then crossed with mice harboring: (1) constitutive beta-catenin activation (Pde8b+/-;ΔCat) and (2) Prkar1a haploinsufficieny...

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PMID: 33338547
DOI: 10.1016/j.mce.2020.111117

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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