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Article

A phosphodiesterase 11 (Pde11a) knockout mouse expressed functional but reduced Pde11a: Phenotype and impact on adrenocortical function.

Molecular and cellular endocrinology - 15 Jan 2021

Levy Isaac, Szarek Eva, Maria Andrea Gutierrez, Starrost Matthew, De La Luz Sierra Maria, Faucz Fabio R, Stratakis Constantine A

Abstract excerpt

Phosphodiesterases catalyze the hydrolysis of cyclic nucleotides and maintain physiologic levels of intracellular concentrations of cyclic adenosine and guanosine mono-phosphate (cAMP and cGMP, respectively). Increased cAMP signaling has been associated with adrenocortical tumors and Cushing syndrome. Genetic defects in phosphodiesterase 11A (PDE11A) may lead to increased cAMP signaling and have been found to...

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Identifiers

PMID: 33127481
DOI: 10.1016/j.mce.2020.111071
PMCID: PMC7771190

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