Article

PKA drives paracrine crisis and WNT4-dependent testis tumor in Carney complex

2020-12-22

Abstract excerpt

<h4>ABSTRACT</h4> Large Cell Calcifying Sertoli Cell Tumors (LCCSCTs) are among the most frequent lesions occurring in Carney complex (CNC) male patients. Although they constitute a key diagnostic criterion for this rare multiple neoplasia syndrome resulting from inactivating mutations of the tumor suppressor PRKAR1A leading to unrepressed PKA activity, the LCCSCT pathogenesis and origin remain elusive. Mouse mo...

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Literature Corpus work: 06713f27-c6f0-5b6d-9d5d-e8e9e830b922
DOI: 10.1101/2020.12.21.423735

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