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Article

Dissecting the p53-Mdm2 feedback loop in vivo: uncoupling the role in p53 stability and activity.

Oncotarget - 15 Mar 2014

Pant Vinod, Lozano Guillermina

Abstract excerpt

The p53-Mdm2 feedback loop is thought to be the main mechanism by which p53 autoregulates its levels and activity after DNA damage. We tested this paradigm in a genetically engineered mouse model in which the feedback loop was disrupted by point mutations in the p53 binding site of the Mdm2 promoter. We noted that while the p53-Mdm2 feedback loop is required to regulate p53 activity especially in the...

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Identifiers

PMID: 24658419
DOI: 10.18632/oncotarget.1797
PMCID: PMC4012731

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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