Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The EMT spectrum and therapeutic opportunities.

Molecular oncology - 1 Jul 2017

Voon Dominic C, Huang Ruby Y, Jackson Rebecca A, Thiery Jean P

Abstract excerpt

Carcinomas are phenotypically arrayed along an epithelial-mesenchymal transition (EMT) spectrum, a developmental program currently exploited to understand the acquisition of drug resistance through a re-routing of growth factor signaling. This review collates the current approaches employed in developing therapeutics against cancer-associated EMT, and provides an assessment of their respective strengths and...

Topics

Join the communities discussing this publication.

Epigenesis, Genetic
Epithelial-Mesenchymal Transition
Cancer Cells and Metastasis
Drug Resistance, Neoplasm
Gene Expression Regulation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Signal Transduction

Source

Open in PubMed Open full text

Identifiers

PMID: 28544151
DOI: 10.1002/1878-0261.12082
PMCID: PMC5496500

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The EMT spectrum and therapeutic opportunities.PMID 28544151Read ↗

Therapeutic Targeting of Epithelial Plasticity Programs: Focus on the Epithelial-Mesenchymal TransitionSemantic proximity Read ↗

Epithelial-mesenchymal transition in carcinoma: navigating phenotypic states to target resistance and metastasis.Semantic proximity Read ↗

Harnessing Carcinoma Cell Plasticity Mediated by TGF-β SignalingSemantic proximity Read ↗

Understanding the Complex Milieu of Epithelial-Mesenchymal Transition in Cancer Metastasis: New Insight Into the Roles of Transcription FactorsSemantic proximity Read ↗

Factors Determining Epithelial-Mesenchymal Transition in Cancer ProgressionSemantic proximity Read ↗

EMT and MET: necessary or permissive for metastasis?Semantic proximity Read ↗

Targeting Tumor Heterogeneity and Epithelial-Mesenchymal Plasticity (EMP) by Anti-Hallmark Combinations, Timing, and Sequencing (CTS) Strategy: Theoretical Basis, Hypothesis, and Proposed ProtocolSemantic proximity Read ↗

Epithelial to Mesenchymal Transition in a Clinical PerspectiveSemantic proximity Read ↗

Epithelial–mesenchymal transition in cancer development and its clinical significanceSemantic proximity Read ↗

Interplay between tumor microenvironment and partial EMT as the driver of tumor progressionSemantic proximity Read ↗

Epithelial-to-mesenchymal transition: lessons from development, insights into cancer and the potential of EMT-subtype based therapeutic interventionSemantic proximity Read ↗

EMTome: a resource for pan-cancer analysis of epithelial-mesenchymal transition genes and signaturesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.