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Article

The S1 protein of SARS-CoV-2 crosses the blood-brain barrier in mice.

Nature neuroscience - 1 Mar 2021

Rhea Elizabeth M, Logsdon Aric F, Hansen Kim M, Williams Lindsey M, Reed May J, Baumann Kristen K, Holden Sarah J, Raber Jacob, Banks William A, Erickson Michelle A

Abstract excerpt

It is unclear whether severe acute respiratory syndrome coronavirus 2, which causes coronavirus disease 2019, can enter the brain. Severe acute respiratory syndrome coronavirus 2 binds to cells via the S1 subunit of its spike protein. We show that intravenously injected radioiodinated S1 (I-S1) readily crossed the blood-brain barrier in male mice, was taken up by brain regions and entered the parenchymal brain...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33328624
DOI: 10.1038/s41593-020-00771-8
PMCID: PMC8793077

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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