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The SARS-CoV-2 envelope protein disrupts barrier function in an in vitro human blood-brain barrier model

23 Aug 2022

Abstract excerpt

Patients with coronavirus disease 2019 (COVID-19) have been frequently reported to exhibit neurological manifestations and disruption of the blood-brain barrier (BBB). Among the risk factors for BBB breakdown, the loss of endothelial cells and pericytes has caused widespread concern. Recent studies have revealed that severe acute respiratory syndrome coronavirus 2 envelope (S2E) protein caused cell death. We...

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PMID: 36082238
DOI: 10.3389/fncel.2022.897564

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