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Acute lung injury induced by recombinant SARS-CoV-2 spike protein subunit S1 in mice

19 Feb 2025

Abstract excerpt

BACKGROUND: The intricacies of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing acute lung injury (ALI) and modulating inflammatory factor dynamics in vivo remain poorly elucidated. The present study endeavors to explore the impact of the recombinant SARS-CoV-2 spike protein S1 subunit (S1SP) on ALI and inflammatory factor profiles in mice, aiming to uncover potential therapeutic targets and...

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PMID: 39972348
DOI: 10.1186/s12931-025-03143-7

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