Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Sirtuin 3 Deficiency Accelerates Hypertensive Cardiac Remodeling by Impairing Angiogenesis.

Journal of the American Heart Association - 19 Aug 2017

Wei Tong, Huang Gaojian, Gao Jing, Huang Chenglin, Sun Mengwei, Wu Jian, Bu Juan, Shen Weili

Abstract excerpt

BACKGROUND: Emerging evidence indicates that impaired angiogenesis may contribute to hypertension-induced cardiac remodeling. The nicotinamide adenine dinucleotide-dependent deacetylase Sirtuin 3 (SIRT3) has the potential to modulate angiogenesis, but this has not been confirmed. As such, the aim of this study was to examine the relationship between SIRT3-mediated angiogenesis and cardiac remodeling. METHODS AND...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cardiomegaly
Share to Collagen Type III

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, 129 Strain

Share to Mitochondria, Heart

Share to Mitophagy

Share to Sirtuin 3

Share to Tissue Culture Techniques

Share to Ventricular Remodeling

Source

Open in PubMed Open full text

Identifiers

PMID: 28862956
DOI: 10.1161/JAHA.117.006114
PMCID: PMC5586452

Genes

SIRT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Sirtuin 3 Deficiency Accelerates Hypertensive Cardiac Remodeling by Impairing Angiogenesis.PMID 28862956Read ↗

Endothelial specific SIRT3 deletion impairs glycolysis and angiogenesis and causes diastolic dysfunction.Semantic proximity Read ↗

SIRT3 (Sirtuin-3) Prevents Ang II (Angiotensin II)-Induced Macrophage Metabolic Switch Improving Perivascular Adipose Tissue Function.Semantic proximity Read ↗

Sirt3 deficiency exacerbates diabetic cardiac dysfunction: Role of Foxo3A-Parkin-mediated mitophagySemantic proximity Read ↗

Signal transducer and activator of transcription 3 is required for myocardial capillary growth, control of interstitial matrix deposition, and heart protection from ischemic injury.Semantic proximity Read ↗

Kindlin‐3 Promotes Angiogenesis via Notch Signalling and Is Crucial for Functional Recovery Postmyocardial InfarctionSemantic proximity Read ↗

SIRT3: A New Regulator of Cardiovascular DiseasesSemantic proximity Read ↗

SIRT3-mediated cardiac remodeling/repair following myocardial infarctionSemantic proximity Read ↗

Sirtuin 3 Deficiency Is Associated with Inhibited Mitochondrial Function and Pulmonary Arterial Hypertension in Rodents and HumansSemantic proximity Read ↗

Abnormalities in the SIRT1-SIRT3 axis promote myocardial ischemia-reperfusion injury through ferroptosis caused by silencing the PINK1/Parkin signaling pathwaySemantic proximity Read ↗

SIRT3 deficiency impairs mitochondrial and contractile function in the heartSemantic proximity Read ↗

Abnormalities in the SIRT1-SIRT3 axis promote myocardial ischemia-reperfusion injury through ferroptosis caused by silencing the PINK1/Parkin signalling pathwaySemantic proximity Read ↗

Cardiomyocyte specific CD38 deletion protects heart from acute myocardial infarction by activating Sirt3 signaling pathwaySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.