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Article

Adipocyte SIRT1 controls systemic insulin sensitivity by modulating macrophages in adipose tissue.

EMBO reports - 1 Apr 2017

Hui Xiaoyan, Zhang Mingliang, Gu Ping, Li Kuai, Gao Yuan, Wu Donghai, Wang Yu, Xu Aimin

Abstract excerpt

Adipose tissue inflammation, characterized by augmented infiltration and altered polarization of macrophages, contributes to insulin resistance and its associated metabolic diseases. The NAD+-dependent deacetylase SIRT1 serves as a guardian against metabolic disorders in multiple tissues. To dissect the roles of SIRT1 in adipose tissues, metabolic phenotypes of mice with selective ablation of SIRT1 in adipocytes...

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Share to Adipocytes
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28270525
DOI: 10.15252/embr.201643184
PMCID: PMC5376747

Genes

SIRT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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