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Article

The Cytidine Deaminase APOBEC3 Family Is Subject to Transcriptional Regulation by p53.

Molecular cancer research : MCR - 1 Jun 2017

Menendez Daniel, Nguyen Thuy-Ai, Snipe Joyce, Resnick Michael A

Abstract excerpt

The APOBEC3 (A3) family of proteins are DNA cytidine deaminases that act as sentinels in the innate immune response against retroviral infections and are responsive to IFN. Recently, a few A3 genes were identified as potent enzymatic sources of mutations in several human cancers. Using human cancer cells and lymphocytes, we show that under stress conditions and immune challenges, all A3 genes are direct...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28232385
DOI: 10.1158/1541-7786.MCR-17-0019
PMCID: PMC5457717

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